Renin-Angiotensin System and Cardiovascular Functions

Renin-angiotensin system and unilateral ureteral obstruction

Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...

Renin angiotensin system and gender differences in the cardiovascular system.

In the effort to explain gender-related differences of the cardiovascular system, the renin-angiotensin system experienced intensive exploration. Indeed, the development of hypertension as well as the progression of coronary artery disease and heart failure have two factors in common: (1) display distinct gender specific characteristics and (2) are enhanced by the renin-angiotensin system. It i...

Cardiovascular disease and genetics of the renin-angiotensin system.

The renin angiotensin system and cardiovascular disease: hope or hype?

Introduction Inhibition of the renin-angiotensin-aldosterone system (RAAS) either via ACE-inhibition, or more recently via the use of angiotensin II receptor antagonists (AIIAs), has become an important therapeutic tool for the treatment of hypertension and its cardiovascular sequelae. Basic scientific investigation of the pathophysiology of cardiovascular disease has revealed many compelling r...

Cardiovascular effects of small peptides of the renin angiotensin system

The renin-angiotensin system (RAS) is a unique hormonal cascade which is composed by multiple enzymes and effector peptides. Recently, new peptides presenting biological activity have been discovered, increasing the complexity of the RAS Here, we evaluated the effects of small peptides of the RAS in coronary bed of rats. Firstly, we examined the direct effect of small angiotensinergic peptides ...